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Here are a few snapshots from the lab. A full publication list can be found here.

Evolutionary adaptation of the α/β-hydrolase fold

Using an integrative approach we explain how a class of dioxygenases have evolved to employ the α/β-hydrolase to achieve cofactor-less oxygenolytic catalysis.

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Refmac5 goes neutron

Thanks to the work of Lucrezia Catapano as part of a collaboration with the group of Garib Murshudov at the MRC-LMB in Cambridge, Refmac5 of the CCP4 suite can now refine macromolecular neutron structures using novel algorithms. 

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Our first dip into 
serial synchrotron crystallography

Room-temperature serial crystallography experiment using the CFEL TapeDrive. This paper is part of a virtual thematic issue on room-temperature biological crystallography.  

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Joint neutron/X-ray crystal structure of a mechanistically relevant complex of perdeuterated urate oxidase and simulations provide insight into the hydration step of catalysis

Looking directly at hydrogens. Work carried out at the ILL LADI-III beamline and great help with the calculations from the Rosta Lab now at UCL. Congratulations to Lindsay on her first paper from her PhD.

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